Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man

Somatostatin was infused for 6 h into seven normal subjects with and without a replacement dose of glucagon. The addition of glucagon to somatostatin resulted in a 30-40% rise in plasma glucagon, whereas plasma insulin declined by 40-50% in both treatment groups. Plasma glucose and glucose production initially increased 2-fold with glucagon replacement, and subsequently declined by 2-3 h to levels comparable to those observed with somatostatin alone. After 6 h plasma glucose and glucose kinetics were no different whether or not glucagon was present. The rise in blood ketones after somatostatin was not exaggerated by glucagon replacement. We conclude that glucagon lack is not a modifying factor in the late hyperglycemic and hyperketonemic response to prolonged infusions of somatostatin.     

Revising Our Mission

This issue's column presents highlights from our 2006 editorial board meeting to help you better understand where we see the magazine going.     

Impact of wind generation on the operation and development of the UK electricity systems

Although penetration of wind generation may displace a significant amount of energy produced by large conventional plant, there are issues associated with the extent to which wind generation will be able to replace the capacity and flexibility of conventional generating plant. This is important since wind power is variable, so it will be necessary to retain a significant proportion of conventional plant to ensure security of supply especially under conditions of high demand and low wind. Hence, the capacity value of wind generation will be limited as it will not be possible to displace conventional generation capacity on a “megawatt for megawatt” basis. Wind power is variable and not easy to predict, hence various forms of additional reserves will be needed to maintain the balance between supply and demand at all times. Additionally, if the majority of wind generation plant is located in Scotland and the North of England, reinforcement of the transmission network will be needed to accommodate the increases in the north-south flow of electricity.     

Review of Meeting Movies.

Reviews the book, Meeting Movies by Norman N. Holland (see record 2006-11509-000). Meeting Movies is a very personal book in which Holland discusses eight films that have been personally meaningful to him. These films are Casablanca, Vertigo, The Seventh Seal, Freud, Persona, Children of Paradise, Shakespeare in Love, and 8 1/2. Holland describes what he was doing with his life when he saw each of these films, and he discusses how each film affected his life and his career. Some of the movies were seen relatively recently, and some were first viewed over half a century ago. In reading the book, it becomes apparent that Holland loves films. Whenever text is in Roman type, Holland is operating in his reader-response critic mode, and the discussion reads much like any other film criticism. However, the most interesting parts of the book occur when Holland is in free association mode, writing about whatever thoughts the movie being discussed brings to mind. These instances are set off from the regular text by use of italicized text. In summary, Meeting Movies is a good read. Holland is well versed in psychology and especially psychoanalytic approaches, and his criticism of these eight films is consistently interesting. His willingness to self-disclose makes this book all the more fascinating. The book will be rewarding for anyone genuinely interested in the interface of psychology and film. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Towards a re-programmable DNA computer

Microreactors lend themselves to a relatively simple implementation of DNA computing. Not only is the design of the DNA library critical for the success of the system but also the architecture of the microfluidic structure. Microreactors can be configured as Boolean operators. This paper will show that biomolecular computing can be performed with elementary building blocks, analogous to electronic logic gates. These logical operations will be performed using negative selection. Furthermore, an alternative bead barrier is introduced which can render the computer re-programmable and shows an principle architecture for selection and analysis.     

Hierarchical edge bundles: visualization of adjacency relations in hierarchical data

A compound graph is a frequently encountered type of data set. Relations are given between items, and a hierarchy is defined on the items as well. We present a new method for visualizing such compound graphs. Our approach is based on visually bundling the adjacency edges, i.e., non-hierarchical edges, together. We realize this as follows. We assume that the hierarchy is shown via a standard tree visualization method. Next, we bend each adjacency edge, modeled as a B-spline curve, toward the polyline defined by the path via the inclusion edges from one node to another. This hierarchical bundling reduces visual clutter and also visualizes implicit adjacency edges between parent nodes that are the result of explicit adjacency edges between their respective child nodes. Furthermore, hierarchical edge bundling is a generic method which can be used in conjunction with existing tree visualization techniques. We illustrate our technique by providing example visualizations and discuss the results based on an informal evaluation provided by potential users of such visualizations     

Completeness in Two-Party Secure Computation: A Computational View

A Secure Function Evaluation (SFE) of a two-variable function f(·,·) is a protocol that allows two parties with inputs x and y to evaluate f(x,y) in a manner where neither party learns "more than is necessary". A rich body of work deals with the study of completeness for secure two-party computation. A function f is complete for SFE if a protocol for securely evaluating f allows the secure evaluation of all (efficiently computable) functions. The questions investigated are which functions are complete for SFE, which functions have SFE protocols unconditionally and whether there are functions that are neither complete nor have efficient SFE protocols. The previous study of these questions was mainly conducted from an information theoretic point of view and provided strong answers in the form of combinatorial properties. However, we show that there are major differences between the information theoretic and computational settings. In particular, we show functions that are considered as having SFE unconditionally by the combinatorial criteria but are actually complete in the computational setting. We initiate the fully computational study of these fundamental questions. Somewhat surprisingly, we manage to provide an almost full characterization of the complete functions in this model as well. More precisely, we present a computational criterion (called computational row non-transitivity) for a function f to be complete for the asymmetric case. Furthermore, we show a matching criterion called computational row transitivity for f to have a simple SFE (based on no additional assumptions). This criterion is close to the negation of the computational row non-transitivity and thus we essentially characterize all "nice" functions as either complete or having SFE unconditionally.     

Subsecond voltammetric separation between dopamine and serotonin in the presence of ascorbate

Although voltammetry has proved an important tool for unraveling the dynamics of specific neurotransmitter molecules during the past decade, it has been very difficult to monitor more than one neurotransmitter simultaneously. In this work, we present a voltammetric methodology that allows discrimination between dopamine and serotonin, two important neurotransmitter molecules with very similar electrochemical properties, in the presence of high concentrations of ascorbate. We combined the application of a novel large-amplitude/high-frequency voltage excitation with signal processing techniques valid for the analysis of nonstationary and nonlinear phenomena. This allows us to minimize the contribution from capacitance and preserve the faradaic features of the voltammetric response providing us with excellent voltammetric detail. Using appropriate voltage excitation parameters and defining specific regions in the voltage space, so-called voltage windows, we can measure the concentrations of dopamine and serotonin separately or independently in mixed solutions even in the presence of high concentrations of ascorbate. Because of the enhanced voltammetric detail of this new technique, it is also possible to explore effects attributed to interfacial phenomena such as adsorption/desorption and electrode fouling.